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Successful In Vitro Screening Strategies For Drug Discovery

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"Successful In Vitro Screening Strategies For Drug Discovery"

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As you start to consider what an appropriate screening cascade should look like, it is important to define what key properties you are looking for in your candidate drug, as these will impact the choice of assays you may deploy in your screening cascade. Screening cascades will develop and change as the molecules progress—a cascade that is put in place during the hit-to-lead phase can and will look very different from the cascade during the lead optimization phase. 

This eBook describes some key factors worth considering as you think through how to construct an effective and robust screening cascade. We will focus initially on the hit-to-lead phase, as this encompasses the types of assays required and highlights some general considerations. Following this, we will explore some of the key differences in screening cascades as the project moves into the lead optimization phase.


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